Ultramax Equine Liquid Wormer for Horses

Ultramax Equine Liquid Tapewormer, Broad Spectrum Wormer and Boticide for horses.

Active Constituents: 75 mg/mL PRAZIQUANTEL 10 mg/mL IVERMECTIN

Ultramax Equine (ivermectin and praziquantel) has been formulated for administration by oral drench or stomach tube (nasogastric intubation).  One low-volume dose is effective against important internal parasites, including tapeworms and the arterial stages of  Strongylus vulgaris, and bots.

Ivermectin is derived from the avermectins, a family of potent, broad-spectrum antiparasitic agents, which are isolated from fermentation of Streptomyces avermitilis.

Praziquantel is indicated for the treatment of tapeworms (Anoplocephala magna,  Paranoplecephala mamillana (adult, immature, heads, segments).

Mode of Action Ivermectin is a member of the macrocyclic lactone class of endectocides which have a unique mode of action. Compounds of the class bind selectively and with high affnity to glutamate- gated chloride ion channels which occur in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membranes to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite.Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA).The margin of safety for compounds of this class is attributable to the fact that mammals do not have glutamate-gated chloride channels; the macrocylic lactones have a low affnity for other mammalian ligand-gated chloride channels and they do not readily cross the blood-brain barrier. Praziquantel induces a rapid and sustained paralytic muscle contraction of the tapeworm parasite and tegumental disruption followed by expulsion of the parasite.

Indications: Ultramax Equine when used at the recommended dose rate of 200µg ivermectin per kilogram liveweight and 1.5 mg/kg praziquantel controls the following parasites of horses: Tapeworms:  Anoplocephala perfoliata, Anoplocephala magna, Paranoplacephala mamillana (adult, immature, heads, segments). Large Strongyles: Strongylus vulgaris (adults and arterial larval stages), Strongylus edentatus (both adult and tissue stages), Strongylus equinus (Adults), Tridontophorus spp. (Adults), Craterostomum acuticaudatum (Adults) Small Strongyles:  including benzimidazole resistant strains Cyathostomum spp. (Adults and fourth-stage larvae), Cylicocyclus spp. (Adults and fourth-stage larvae), Cylicostephanus spp. (Adults and fourth-stage larvae), Cylicodontophorus spp. (Adults and fourth-stage larvae), Gyalocephalus spp. (Adults and fourth-stage larvae), Coronocyclus spp. (Adults and fourth-stage larvae), Parapoteriostomum spp. (Adults and fourth-stage larvae), Petrovinema spp. (Adults and fourth-stage larvae), Poteriostomum spp. (Adults and fourth-stage larvae) Pinworms:  Oxyuris equi (Adults and fourth-stage larvae) Ascarids:  Parascaris equorum (Adults and fourth-stage larvae) Bots:  Gasterophilus spp. (oral and gastric stages) Hairworms:  Trichostrongylus axei (Adult) Intestinal Threadworms:  Strongyloides westeri (adult) Large Mouth Stomach Worms:  Habronema muscae (adult) Lungworms:  Dictyocaulus arnfedi (adult and immature) Ultramax Equine also controls skin lesions caused by cutaneous larvae of Habronema and Draschia spp. (summer sores), and Onchocerca spp., microflaraiae (cutaneous onchocerciasis)

Directions for Use: SHAKE WELL BEFORE USE The recommended dose is 1mL Ultramax Equine per 50kg liveweight (equivalent to 200µg ivermectin per kg liveweight and 1.5 mg praziquantel per kg liveweight). Ultramax Equine can be given as an oral drench or by stomach tube (nasogastric intubation).  Nasogastric intubation should only be done by a veterinarian or under veterinary supervision.Administration by oral drench: For administration by this method, an undiluted dose is usually preferred.  Clear the horse’s mouth of any food material,